25羟维生素D水平与中国狼疮患者绝经前代谢综合征有关
日期:2018-07-19


  目的:本研究的目的是为探讨绝经前中国SLE患者25羟维生素D(25(OH)VitD)的表达水平及其与代谢综合征(MS)及其组分异常的关系。


  方法:在这项横断面研究中,共纳入113例绝经前SLE患者,并招募了年龄匹配的健康人群作为对照,收集临床及实验室资料,包括血清25(OH)VitD表达水平。多变量分析法分析25(OH)VitD与MS及其组分异常的关系。


  结果:25(OH)VitD缺乏(<20ng/ml)及MS在绝经前中国SLE患者中普遍存在(分别为24.8%和30.1%)。25(OH)VitD、MS及其组分异常之间的相关分析显示:25(OH)VitD低表达与MS患病率增加有关(OR=0.920,p=0.012),与高密度脂蛋白水平降低相关(OR=1.059,p=0.033),与空腹血糖水平升高相关(OR=0.810,p=0.004)。这些相关性在调整年龄、体重指数及与SLE相关的变量后仍存在。


  结论:25(OH)VitD表达水平与中国狼疮患者绝经前代谢综合征及其组分异常有关。


  附原文:Abstract:Objective:Thisstudyaimedtoinvestigatethestatusof25-hydroxyvitaminD(25(OH)D)anditsassociationwithmetabolicsyndrome(MS)anddifferentMScomponentsamongpremenopausalwomenwithsystemiclupuserythematosus(SLE)inChina.Patientsandmethods:Altogether113premenopausalwomenwithSLEandtheage-matchedhealthycohortswere


  recruitedinthiscross-sectionalstudy.Clinicalmanifestationsandlaboratorydataincludingserum25(OH)Dconcentrationwerecollected.Amultivariableanalysiswasperformedtoanalyzetheassociationof25(OH)DwithMSanditscomponents.Results:Theprevalenceof25(OH)Ddeficiency(25(OH)D<20ng/ml)andMSwerecommon(24.8%and30.1%,respectively)inpremenopausalpatientswithSLEinChina.Analysisoftheassociationbetween25(OH)D,MSanditscomponentsdemonstratedthatthelowerlevelof25(OH)DwasassociatedwithincreasedMSprevalence(OR=0.920,p=0.012),adecreasedlevelofhigh-densitylipoprotein(OR=1.059,p=0.033)andahigherleveloffastingglucose(OR=0.810,p=0.004).Theseassociationswerestilldetectibleafteradjustmentforage,bodymassindexandSLE-relatedvariables.Conclusion:Thelevelof25(OH)DisassociatedwithMSanditscomponentsinpremenopausalwomenwithSLE


  引自:WangLM,ZhengZH,LiTF,etal.25-hydroxyvitaminDisassociatedwithmetabolicsyndromeamongpremenopausalwomenwithsystemiclupuserythematosusinChina[J].Lupus,2017,26(4):403–409.